Blar i forfatter "Larsen, Terje"

Viser treff 1-11 av 11

    • The acute phase of experimental cardiogenic shock is counteracted by microcirculatory and mitochondrial adaptations 

      Stenberg, Thor Allan; Kildal, Anders Benjamin; Sanden, Espen; How, Ole-Jakob; Hagve, Martin; Ytrehus, Kirsti; Larsen, Terje; Myrmel, Truls (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)

    • Administration of tetradecylthioacetic acid (TTA) stimulates myocardial fatty acid oxidation despite having a lipid-lowering effect 

      Severson, DL; Hafstad, Anne Dragøy; Khalid, Ahmed Murtaz; Clarke, Kieran; Hagve, Martin; Berge, Rolf; Lund, trine; Larsen, Terje; Aasum, Ellen (Journal article; Tidsskriftartikkel; Peer reviewed, 2009)

    • Altered mitochondrial metabolism in the insulin-resistant heart 

      Makrecka-Kuka, Marina; Liepinsh, Edgars; Murray, Andrew J.; Lemieux, Hélène; Dambrova, Maija; Tepp, Kersti; Puurand, Marju; Käämbre, Tuuli; Han, Woo H.; de Goede, Paul; O'Brien, Katie A.; Turan, Belma; Tuncay, Erkan; Olgar, Yusuf; Rolo, Anabela P.; Palmeira, Carlos M.; Boardman, Neoma Tove; Wüst, Rob C.I.; Larsen, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-16)
      Obesity‐induced insulin resistance and type 2 diabetes mellitus can ultimately result in various complications, including diabetic cardiomyopathy. In this case, cardiac dysfunction is characterized by metabolic disturbances such as impaired glucose oxidation and an increased reliance on fatty acid (FA) oxidation. Mitochondrial dysfunction has often been associated with the altered metabolic function ...

    • Dietary calanus oil recovers metabolic flexibility and rescues postischemic cardiac function in obese female mice 

      Jansen, Kirsten; Moreno, Sonia; Garcia-Roves, Pablo M; Larsen, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-07-16)
      The aim of this study was to find out whether dietary supplementation with Calanus oil (a novel marine oil) or infusion of exenatide (an incretin mimetic) could counteract obesity-induced alterations in myocardial metabolism and improve postischemic recovery of left ventricular (LV) function. Female C57bl/6J mice received high-fat diet (HFD, 45% energy from fat) for 12 wk followed by 8-wk feeding ...

    • Exercise training combined with calanus oil supplementation improves the central cardiodynamic function in older women 

      Štěpán, Marek; Dad’ová, Klára; Matouš, Miloš; Krauzová, Eva; Sontáková, Lenka; Koc, Michal; Larsen, Terje; Kuda, Ondrej; Štich, Vladimír; Rossmeislová, Lenka; Šiklová, Michaela (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-29)
      The aim of this study was to investigate the possible beneficial effects of exercise training (ET) with omega-3/Calanus oil supplementation on cardiorespiratory and adiposity parameters in elderly women. Fifty-five women (BMI: 19–37 kg/m<sup>2</sup> , 62–80 years old) were recruited and randomly assigned to the 4 month intervention with ET and omega-3 supplementation (Calanus oil, ET-Calanus) ...

    • Impact of GLP-1 receptor agonist versus omega-3 fatty acids supplement on obesity-induced alterations of mitochondrial respiration 

      Jansen, Kirsten Maria; Dahdah, Norma; Gama-Perez, Pau; Schots, Pauke C.; Larsen, Terje; Garcia-Roves, Pablo M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-23)
      Objective: To compare administration of the glucagon-like peptide-1 (GLP-1) analogue, exenatide, versus dietary supplementation with the omega-3 fatty acid-rich Calanus oil on obesity-induced alterations in mitochondrial respiration.<p> <p>Methods: Six-week-old female C57BL/6JOlaHSD mice were given high fat diet (HFD, 45% energy from fat) for 12 weeks to induce obesity. Thereafter, they were ...

    • Impact of obesity-related inflammation on cardiac metabolism and function 

      Larsen, Terje; Jansen, Kirsten (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-10)
      This review focuses on the role of adipose tissue in obese individuals in the development of metabolic diseases, and their consequences for metabolic and functional derangements in the heart. The general idea is that the expansion of adipocytes during the development of obesity gives rise to unhealthy adipose tissue, characterized by low-grade inflammation and the release of proinflammatory ...

    • No Effect of Calanus Oil on Maximal Oxygen Uptake in Healthy Participants: A Randomized Controlled Study 

      Tauschek, Lucas Christian; Røsbjørgen, Ragnhild; Dalen, Håvard; Larsen, Terje; Karlsen, Trine (Journal article; Tidsskriftartikkel, 2022-08-23)
      We aimed to investigate the long-term effect of daily Calanus oil supplementation on maximal oxygen uptake (VO<sub>2</sub>max) in healthy 30- to 50-year-old participants. The study was motivated by preclinical studies reporting increased VO<sub>2</sub>max and metabolic health with omega-3 rich Calanus oil. In a double-blinded study, 71 participants were randomized to receive 2 g/day of Calanus or ...

    • Possible Health Effects of a Wax Ester Rich Marine Oil 

      Schots, Pauke C.; Pedersen, Alice Marie; Eilertsen, Karl-Erik; Olsen, Ragnar Ludvig; Larsen, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-26)
      The consumption of seafood and the use of fish oil for the production of nutraceuticals and fish feed have increased over the past decades due the high content of long-chain polyunsaturated omega-3 fatty acids. This increase has put pressure on the sustainability of fisheries. One way to overcome the limited supply of fish oil is to harvest lower in the marine food web. <i>Calanus finmarchicus</i>, ...

    • Proteases in plasma and kidney of db /db mice as markers of diabetes-induced nephropathy 

      Hadler-Olsen, Elin Synnøve; Winberg, Jan-Olof; Reinholt, Finn P.; Larsen, Terje; Uhlin-Hansen, Lars; Jenssen, Trond Geir; Berg, Eli; Kolset, Svein Olav (Journal article; Tidsskriftartikkel; Peer reviewed, 2011)
      Db/db mice are overweight, dyslipidemic and develop diabetic complications, relevant for similar complications in human type 2 diabetes. We have used db/db and db/+ control mice to investigate alterations in proteinase expression and activity in circulation and kidneys by SDS-PAGE zymography, electron microscopy, immunohistochemistry, Western blotting, and in situ zymography. Plasma from db/db mice ...

    • Two Isomeric C16 Oxo-Fatty Acids from the Diatom Chaetoceros karianus Show Dual Agonist Activity towards Human Peroxisome Proliferator-Activated Receptors (PPARs) α/γ 

      Moldes-Anaya, Angel; Sæther, Thomas; Uhlig, Silvio; Nebb, Hilde Irene; Larsen, Terje; Eilertsen, Hans Christian; Paulsen, Steinar Martin (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-05-25)
      The peroxisome proliferator-activated receptors (PPARs) function as ligand-activated transcription factors that convert signals in the form of lipids to physiological responses through the activation of metabolic target genes. Due to their key roles in lipid and carbohydrate metabolism, the PPARs are important drug targets. However, for several of the PPAR drugs currently in use, adverse side effects ...